Urease

From Biocrawler, the free encyclopedia.

Urease (EC 3.5.1.5 (http://us.expasy.org/cgi-bin/nicezyme.pl?3.5.1.5)) is an enzyme that catalyzes the hydrolysis of urea into carbon dioxide and ammonia. The reaction occurs as follows: (NH₂)₂CO + H₂O → CO₂ + NH₃

In 1926 James Sumner shows that urease is a protein. Urease is found in bacteria, yeast and several higher plants.

Characteristics:

• Molecular weight : 480 kDa
• Optimum pH : 7.4
• Enzymatic specificity: urea and hydroxyurea
• Inhibitors : heavy metals, sodium, potassium

A specific urease (which may be used in diagnosis) occurs in Helicobacter pylori.

Wikipedia (http://en.wikipedia.org/wiki/Main_Page) Urease (http://en.wikipedia.org/wiki/Urease) version history (http://en.wikipedia.org/w/index.php?title=Urease&action=history) GNU Free Documentation Lizenz (http://en.wikipedia.org/wiki/Wikipedia:Text_of_the_GNU_Free_Documentation_License) CC-by-sa (http://creativecommons.org/licenses/by-sa/2.5/)

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