Thrombospondin
From Biocrawler, the free encyclopedia.
Thrombospondins are secreted proteins with the ability to inhibit angiogenesis. Overexpression of TSPs in tumor cells results in reduced angiogenesis. Inhibitory peptides and fragments of TSP1 bind to CD36, leading to the expression of FasL, which activates the expression of Fas. This leads to the activation of caspases and apoptosis of the cell.
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