Sphingosine
From Biocrawler, the free encyclopedia.
Sphingosine is a compound that forms a primary part of sphingomyelin, an important phospholipid. Sphingosine can be phosphorylated in vivo via two kinases, sphingosine kinase type 1 and sphingosine kinase type 2.
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Synthesis
Sphingosine is synthesized from palmitoyl CoA and serine in a condensation requires to yield dehydrosphingosine. Dehydrosphingosine is then reduced by NADPH to dihydrosphingosine, and finally oxidized by FAD to sphingosine.
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