Simmons-Smith reaction

From Biocrawler, the free encyclopedia.

The Simmons-Smith reaction is a organic reaction in which a carbenoid reacts to an alkene or a alkyne to form a cyclopropane. Thus, cyclohexene, methylene iodide and a zinc-copper couple yield bicyclo[4.1.0]heptane.

References

Simmons, H.E.; Smith, R.D. J. Am. Chem. Soc., 1958, 80, 5323. Simmons, H.E.; Smith, R.D. J. Am. Chem. Soc., 1959, 81, 4256. Denis, J.M.; Girard, J.M.; Conia, J.M. Synthesis., 1972, 549.

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