Hofmann rearrangement
From Biocrawler, the free encyclopedia.
The Hofmann rearrangement is an organic reaction in which a primary amide is converted to an amine upon treatment with bromine and a suitable base. The amide reacts with the base and bromine to form an isocyanate intermediate, which then undergoes hydrolysis to form the corresponding amine. The reaction is so named due to the intramolecular migration of the functional group to the adjacent nitrogen following its deprotonation. It is named after August Wilhelm von Hofmann.
