Divergent synthesis
From Biocrawler, the free encyclopedia.
In chemistry a divergent synthesis is a strategy with the aim to improve the effiency of chemical synthesis. It is often an alternative to convergent synthesis or linear synthesis.
In one strategy divergent synthesis aims to generate a library of chemical compounds by first reacting a molecule with a set of reactants. The next generation of compounds is generated by further reactions with each compound in generation 1. This methodology quickly diverges to large numbers of new compounds
- A generates A1, A2, A3, A4, A5 in generation 1
- A1 generates A11, A12, A13 in generation 2 and so on.
The entire library of new chemical compounds for instance sugars [1] (http://www.chem.usu.edu/~tchang/Research/details_unusual_sugar.htm) can then be screened for desirable properties.
In another strategy divergent synthesis starts from a molecule as a central core from which successive generations of building blocks are added. A good example is the divergent synthesis of dendrimers for example [2] (http://www2.chemie.uni-erlangen.de/services/dissonline/data/dissertation/Francesc_Camprubi/html/chapter3-3.html) where in each generation new monomer reacts to the growing surface of the sphere.
