Dedifferentiation
From Biocrawler, the free encyclopedia.
Dedifferentiation is a cellular process commonly believed to be uniquely available to lower life forms such as worms and amphibians in which a partially or terminally differentiated cell reverts to an earlier developmental stage.
Theories
Some believe dedifferentiation is an aberration of the normal development cycle that results in cancer, whereas others believe it to be a natural part of the immune response lost by humans at some point as a result of evolution.
Research
A small molecule dubbed reversine (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15087480), a purine analog, has been discovered that has proven to induce dedifferentiation in myotubes. These dedifferentiated cells were then able to redifferentiate into osteoblasts and adipocytes.
