Cytotoxic T cell
From Biocrawler, the free encyclopedia.
A cytotoxic (or TC) T cell is a T cell (a type of white blood cell) which has on its surface antigen receptors that can bind to fragments of antigens displayed by the Class I MHC molecules of virus infected somatic cells and tumor cells.
Once activated by a MHC-antigen complex, TC cells release the protein perforin, which forms pores in the target cell's plasma membrane; this causes ions and water to flow into the target cell, making it expand and eventually lyse. TC also release granzyme, a serine protease, that can enter target cells via the perforin-formed pore and induce apoptosis (cell death).
Most TC cells have present on the cell surface the protein CD8, which is attracted to portions of the Class I MHC molecule. This affinity keeps the TC cell and the target cell bound closely together during antigen-specific activation. TC cells with CD8 surface protein are called CD8+ T cells.
| Immune system |
| Humoral immune system - Cellular immune system - Lymphatic system |
| White blood cells - B cells - Antibodies - Antigen (MHC) |
| Lymphocytes: T cells (Cytotoxic & Helper) - B cells (Plasma cells & Memory B cells) |
