Brefeldin A

From Biocrawler, the free encyclopedia.

Brefeldin A is a lactone antibiotic produced by fungal organisms such as Eupenicillium brefeldianum. Brefeldin A interferes with protein transport from the endoplasmic reticulum to the Golgi apparatus. In mammalian and yeast cells, the main target of brefeldin A appears to be a certain type of GTP-exchange factors responsible for activating a GTPase called Arf1p ; in turn, Arf1p is involved in the formation of transport vesicles by recruiting coat proteins to intracellular membranes. Brefeldin A was initially isolated as an anti-viral antibiotic [1] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4299889&dopt=Citation) but is now primarily used in biological research to study protein transport.

External links

• Brefeldin A: insights into the control of membrane traffic and organelle structure. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1740466&dopt=Citation) (Review, 1992)
• Brefeldin A: Deciphering an Enigmatic Inhibitor of Secretion. (http://www.plantphysiol.org/cgi/content/full/130/3/1102) (Review, 2002)

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