Acylation

From Biocrawler, the free encyclopedia.

In chemistry, acylation is the process of adding an acyl group to a compound. The compound providing the acyl group is called the acylating agent.

Because they form a strong electrophile when treated with some metal catalysts, acyl halides are commonly used as acylating agents. For example, Friedel-Crafts acylation uses acetyl chloride (CH₃COCl) as the agent and aluminum chloride (AlCl₃) as a catalyst to add an acetyl group to benzene:

Anhydrides of carboxylic acids are also commonly used acylating agents to acylate amines to form amides or acylate alcohols to form esters. Succinic acid is also commonly used in a specific type of acylation called succination. Oversuccination occurs when more than one succinate adds to a single compound.

Related topics

• acetyl
• ketene
• indicator
• chemical synthesis

References

• NIH Thesaurus (http://crisp.cit.nih.gov/Thesaurus/00000094.htm)

External links

• Federal Judicial Affairs of Canada case (http://reports.fja.gc.ca/fc/1997/pub/v2/1997fc19793.html)
• Friedel-Crafts acylation of benzene (http://www.chemguide.co.uk/mechanisms/elsub/fcacyl.html)nl:Friedel-Crafts-acylering

Wikipedia (http://en.wikipedia.org/wiki/Main_Page) Acylation (http://en.wikipedia.org/wiki/Acylation) version history (http://en.wikipedia.org/w/index.php?title=Acylation&action=history) GNU Free Documentation Lizenz (http://en.wikipedia.org/wiki/Wikipedia:Text_of_the_GNU_Free_Documentation_License) CC-by-sa (http://creativecommons.org/licenses/by-sa/2.5/)

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