Activin
From Biocrawler, the free encyclopedia.
Activin is a peptide that enhances FSH synthesis and secretion and participates in the regulation of the menstrual cycle. It does the opposite as inhibin.
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Structure
Activin contains two beta subunit that are identical to the two beta subunits (A or B) of inhibin, allowing for the formation of three forms of activin: A, AB, and B. Like inhibin (and AMH) activin belongs to the transforming growth factor-β (TGF-β) family.
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Action
In the ovarian follicle, activin increases FSH binding and FSH induced aromatization. It participates in androgen synthesis enhancing LH action in the ovary and testis. In the male , activin enhances spermatogenesis. Activin is produced in the gonads, pituitary gland, placenta and other organs.
